Comparative Venomics Reveals the Complex Prey Capture Strategy of the Piscivorous Cone Snail Conus catus.
Identifieur interne : 003018 ( Main/Exploration ); précédent : 003017; suivant : 003019Comparative Venomics Reveals the Complex Prey Capture Strategy of the Piscivorous Cone Snail Conus catus.
Auteurs : S W A. Himaya [Australie] ; Ai-Hua Jin [Australie] ; Sébastien Dutertre [Australie] ; Jean Giacomotto [Australie] ; Hoshyar Mohialdeen [Australie] ; Irina Vetter [Australie] ; Paul F. Alewood [Australie] ; Richard J. Lewis [Australie]Source :
- Journal of proteome research [ 1535-3907 ] ; 2015.
Descripteurs français
- KwdFr :
- Activité motrice (), Animaux, Annotation de séquence moléculaire, Antagonistes nicotiniques (), Antagonistes nicotiniques (isolement et purification), Antagonistes nicotiniques (toxicité), Canaux calciques (métabolisme), Canaux potassiques (métabolisme), Comportement prédateur (physiologie), Conotoxines (), Conotoxines (isolement et purification), Conotoxines (toxicité), Conus (), Conus (physiologie), Danio zébré (physiologie), Données de séquences moléculaires, Inhibiteurs des canaux calciques (), Inhibiteurs des canaux calciques (isolement et purification), Inhibiteurs des canaux calciques (toxicité), Inhibiteurs des canaux potassiques (), Inhibiteurs des canaux potassiques (isolement et purification), Inhibiteurs des canaux potassiques (toxicité), Organismes aquatiques, Récepteurs nicotiniques (métabolisme), Spécificité d'espèce, Séquence d'acides aminés, Transcriptome, Venins de mollusque (), Venins de mollusque (isolement et purification), Venins de mollusque (toxicité).
- MESH :
- isolement et purification : Antagonistes nicotiniques, Conotoxines, Inhibiteurs des canaux calciques, Inhibiteurs des canaux potassiques, Venins de mollusque.
- métabolisme : Canaux calciques, Canaux potassiques, Récepteurs nicotiniques.
- physiologie : Comportement prédateur, Conus, Danio zébré.
- toxicité : Antagonistes nicotiniques, Conotoxines, Inhibiteurs des canaux calciques, Inhibiteurs des canaux potassiques, Venins de mollusque.
- Activité motrice, Animaux, Annotation de séquence moléculaire, Antagonistes nicotiniques, Conotoxines, Conus, Données de séquences moléculaires, Inhibiteurs des canaux calciques, Inhibiteurs des canaux potassiques, Organismes aquatiques, Spécificité d'espèce, Séquence d'acides aminés, Transcriptome, Venins de mollusque.
English descriptors
- KwdEn :
- Amino Acid Sequence, Animals, Aquatic Organisms, Calcium Channel Blockers (chemistry), Calcium Channel Blockers (isolation & purification), Calcium Channel Blockers (toxicity), Calcium Channels (metabolism), Conotoxins (chemistry), Conotoxins (isolation & purification), Conotoxins (toxicity), Conus Snail (chemistry), Conus Snail (physiology), Molecular Sequence Annotation, Molecular Sequence Data, Mollusk Venoms (chemistry), Mollusk Venoms (isolation & purification), Mollusk Venoms (toxicity), Motor Activity (drug effects), Nicotinic Antagonists (chemistry), Nicotinic Antagonists (isolation & purification), Nicotinic Antagonists (toxicity), Potassium Channel Blockers (chemistry), Potassium Channel Blockers (isolation & purification), Potassium Channel Blockers (toxicity), Potassium Channels (metabolism), Predatory Behavior (physiology), Receptors, Nicotinic (metabolism), Species Specificity, Transcriptome, Zebrafish (physiology).
- MESH :
- chemical , chemistry : Calcium Channel Blockers, Conotoxins, Mollusk Venoms, Nicotinic Antagonists, Potassium Channel Blockers.
- chemical , isolation & purification : Calcium Channel Blockers, Conotoxins, Mollusk Venoms, Nicotinic Antagonists, Potassium Channel Blockers.
- chemical , metabolism : Calcium Channels, Potassium Channels, Receptors, Nicotinic.
- chemical , toxicity : Calcium Channel Blockers, Conotoxins, Mollusk Venoms, Nicotinic Antagonists, Potassium Channel Blockers.
- chemistry : Conus Snail.
- drug effects : Motor Activity.
- physiology : Conus Snail, Predatory Behavior, Zebrafish.
- Amino Acid Sequence, Animals, Aquatic Organisms, Molecular Sequence Annotation, Molecular Sequence Data, Species Specificity, Transcriptome.
Abstract
Venomous marine cone snails produce a unique and remarkably diverse range of venom peptides (conotoxins and conopeptides) that have proven to be invaluable as pharmacological probes and leads to new therapies. Conus catus is a hook-and-line fish hunter from clade I, with ∼20 conotoxins identified, including the analgesic ω-conotoxin CVID (AM336). The current study unravels the venom composition of C. catus with tandem mass spectrometry and 454 sequencing data. From the venom gland transcriptome, 104 precursors were recovered from 11 superfamilies, with superfamily A (especially κA-) conotoxins dominating (77%) their venom. Proteomic analysis confirmed that κA-conotoxins dominated the predation-evoked milked venom of each of six C. catus analyzed and revealed remarkable intraspecific variation in both the intensity and type of conotoxins. High-throughput FLIPR assays revealed that the predation-evoked venom contained a range of conotoxins targeting the nAChR, Cav, and Nav ion channels, consistent with α- and ω-conotoxins being used for predation by C. catus. However, the κA-conotoxins did not act at these targets but induced potent and rapid immobilization followed by bursts of activity and finally paralysis when injected intramuscularly in zebrafish. Our venomics approach revealed the complexity of the envenomation strategy used by C. catus, which contains a mix of both excitatory and inhibitory venom peptides.
DOI: 10.1021/acs.jproteome.5b00630
PubMed: 26322961
Affiliations:
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Himaya</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Molecular Bioscience, The University of Queensland , Brisbane, 4072 Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Institute for Molecular Bioscience, The University of Queensland , Brisbane, 4072 Queensland</wicri:regionArea><wicri:noRegion>4072 Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Jin, Ai Hua" sort="Jin, Ai Hua" uniqKey="Jin A" first="Ai-Hua" last="Jin">Ai-Hua Jin</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Molecular Bioscience, The University of Queensland , Brisbane, 4072 Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Institute for Molecular Bioscience, The University of Queensland , Brisbane, 4072 Queensland</wicri:regionArea><wicri:noRegion>4072 Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Dutertre, Sebastien" sort="Dutertre, Sebastien" uniqKey="Dutertre S" first="Sébastien" last="Dutertre">Sébastien Dutertre</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Molecular Bioscience, The University of Queensland , Brisbane, 4072 Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Institute for Molecular Bioscience, The University of Queensland , Brisbane, 4072 Queensland</wicri:regionArea><wicri:noRegion>4072 Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Giacomotto, Jean" sort="Giacomotto, Jean" uniqKey="Giacomotto J" first="Jean" last="Giacomotto">Jean Giacomotto</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Molecular Bioscience, The University of Queensland , Brisbane, 4072 Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Institute for Molecular Bioscience, The University of Queensland , Brisbane, 4072 Queensland</wicri:regionArea><wicri:noRegion>4072 Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Mohialdeen, Hoshyar" sort="Mohialdeen, Hoshyar" uniqKey="Mohialdeen H" first="Hoshyar" last="Mohialdeen">Hoshyar Mohialdeen</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Molecular Bioscience, The University of Queensland , Brisbane, 4072 Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Institute for Molecular Bioscience, The University of Queensland , Brisbane, 4072 Queensland</wicri:regionArea><wicri:noRegion>4072 Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Vetter, Irina" sort="Vetter, Irina" uniqKey="Vetter I" first="Irina" last="Vetter">Irina Vetter</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Molecular Bioscience, The University of Queensland , Brisbane, 4072 Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Institute for Molecular Bioscience, The University of Queensland , Brisbane, 4072 Queensland</wicri:regionArea><wicri:noRegion>4072 Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Alewood, Paul F" sort="Alewood, Paul F" uniqKey="Alewood P" first="Paul F" last="Alewood">Paul F. Alewood</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Molecular Bioscience, The University of Queensland , Brisbane, 4072 Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Institute for Molecular Bioscience, The University of Queensland , Brisbane, 4072 Queensland</wicri:regionArea><wicri:noRegion>4072 Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Lewis, Richard J" sort="Lewis, Richard J" uniqKey="Lewis R" first="Richard J" last="Lewis">Richard J. Lewis</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Molecular Bioscience, The University of Queensland , Brisbane, 4072 Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Institute for Molecular Bioscience, The University of Queensland , Brisbane, 4072 Queensland</wicri:regionArea><wicri:noRegion>4072 Queensland</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of proteome research</title><idno type="eISSN">1535-3907</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Aquatic Organisms</term><term>Calcium Channel Blockers (chemistry)</term><term>Calcium Channel Blockers (isolation & purification)</term><term>Calcium Channel Blockers (toxicity)</term><term>Calcium Channels (metabolism)</term><term>Conotoxins (chemistry)</term><term>Conotoxins (isolation & purification)</term><term>Conotoxins (toxicity)</term><term>Conus Snail (chemistry)</term><term>Conus Snail (physiology)</term><term>Molecular Sequence Annotation</term><term>Molecular Sequence Data</term><term>Mollusk Venoms (chemistry)</term><term>Mollusk Venoms (isolation & purification)</term><term>Mollusk Venoms (toxicity)</term><term>Motor Activity (drug effects)</term><term>Nicotinic Antagonists (chemistry)</term><term>Nicotinic Antagonists (isolation & purification)</term><term>Nicotinic Antagonists (toxicity)</term><term>Potassium Channel Blockers (chemistry)</term><term>Potassium Channel Blockers (isolation & purification)</term><term>Potassium Channel Blockers (toxicity)</term><term>Potassium Channels (metabolism)</term><term>Predatory Behavior (physiology)</term><term>Receptors, Nicotinic (metabolism)</term><term>Species Specificity</term><term>Transcriptome</term><term>Zebrafish (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Activité motrice ()</term><term>Animaux</term><term>Annotation de séquence moléculaire</term><term>Antagonistes nicotiniques ()</term><term>Antagonistes nicotiniques (isolement et purification)</term><term>Antagonistes nicotiniques (toxicité)</term><term>Canaux calciques (métabolisme)</term><term>Canaux potassiques (métabolisme)</term><term>Comportement prédateur (physiologie)</term><term>Conotoxines ()</term><term>Conotoxines (isolement et purification)</term><term>Conotoxines (toxicité)</term><term>Conus ()</term><term>Conus (physiologie)</term><term>Danio zébré (physiologie)</term><term>Données de séquences moléculaires</term><term>Inhibiteurs des canaux calciques ()</term><term>Inhibiteurs des canaux calciques (isolement et purification)</term><term>Inhibiteurs des canaux calciques (toxicité)</term><term>Inhibiteurs des canaux potassiques ()</term><term>Inhibiteurs des canaux potassiques (isolement et purification)</term><term>Inhibiteurs des canaux potassiques (toxicité)</term><term>Organismes aquatiques</term><term>Récepteurs nicotiniques (métabolisme)</term><term>Spécificité d'espèce</term><term>Séquence d'acides aminés</term><term>Transcriptome</term><term>Venins de mollusque ()</term><term>Venins de mollusque (isolement et purification)</term><term>Venins de mollusque (toxicité)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Calcium Channel Blockers</term><term>Conotoxins</term><term>Mollusk Venoms</term><term>Nicotinic Antagonists</term><term>Potassium Channel Blockers</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Calcium Channel Blockers</term><term>Conotoxins</term><term>Mollusk Venoms</term><term>Nicotinic Antagonists</term><term>Potassium Channel Blockers</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Calcium Channels</term><term>Potassium Channels</term><term>Receptors, Nicotinic</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Calcium Channel Blockers</term><term>Conotoxins</term><term>Mollusk Venoms</term><term>Nicotinic Antagonists</term><term>Potassium Channel Blockers</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Conus Snail</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Motor Activity</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Antagonistes nicotiniques</term><term>Conotoxines</term><term>Inhibiteurs des canaux calciques</term><term>Inhibiteurs des canaux potassiques</term><term>Venins de mollusque</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Canaux calciques</term><term>Canaux potassiques</term><term>Récepteurs nicotiniques</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Comportement prédateur</term><term>Conus</term><term>Danio zébré</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Conus Snail</term><term>Predatory Behavior</term><term>Zebrafish</term></keywords><keywords scheme="MESH" qualifier="toxicité" xml:lang="fr"><term>Antagonistes nicotiniques</term><term>Conotoxines</term><term>Inhibiteurs des canaux calciques</term><term>Inhibiteurs des canaux potassiques</term><term>Venins de mollusque</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Aquatic Organisms</term><term>Molecular Sequence Annotation</term><term>Molecular Sequence Data</term><term>Species Specificity</term><term>Transcriptome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Activité motrice</term><term>Animaux</term><term>Annotation de séquence moléculaire</term><term>Antagonistes nicotiniques</term><term>Conotoxines</term><term>Conus</term><term>Données de séquences moléculaires</term><term>Inhibiteurs des canaux calciques</term><term>Inhibiteurs des canaux potassiques</term><term>Organismes aquatiques</term><term>Spécificité d'espèce</term><term>Séquence d'acides aminés</term><term>Transcriptome</term><term>Venins de mollusque</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Venomous marine cone snails produce a unique and remarkably diverse range of venom peptides (conotoxins and conopeptides) that have proven to be invaluable as pharmacological probes and leads to new therapies. Conus catus is a hook-and-line fish hunter from clade I, with ∼20 conotoxins identified, including the analgesic ω-conotoxin CVID (AM336). The current study unravels the venom composition of C. catus with tandem mass spectrometry and 454 sequencing data. From the venom gland transcriptome, 104 precursors were recovered from 11 superfamilies, with superfamily A (especially κA-) conotoxins dominating (77%) their venom. Proteomic analysis confirmed that κA-conotoxins dominated the predation-evoked milked venom of each of six C. catus analyzed and revealed remarkable intraspecific variation in both the intensity and type of conotoxins. High-throughput FLIPR assays revealed that the predation-evoked venom contained a range of conotoxins targeting the nAChR, Cav, and Nav ion channels, consistent with α- and ω-conotoxins being used for predation by C. catus. However, the κA-conotoxins did not act at these targets but induced potent and rapid immobilization followed by bursts of activity and finally paralysis when injected intramuscularly in zebrafish. Our venomics approach revealed the complexity of the envenomation strategy used by C. catus, which contains a mix of both excitatory and inhibitory venom peptides.</div></front></TEI><affiliations><list><country><li>Australie</li></country></list><tree><country name="Australie"><noRegion><name sortKey="Himaya, S W A" sort="Himaya, S W A" uniqKey="Himaya S" first="S W A" last="Himaya">S W A. Himaya</name></noRegion><name sortKey="Alewood, Paul F" sort="Alewood, Paul F" uniqKey="Alewood P" first="Paul F" last="Alewood">Paul F. Alewood</name><name sortKey="Dutertre, Sebastien" sort="Dutertre, Sebastien" uniqKey="Dutertre S" first="Sébastien" last="Dutertre">Sébastien Dutertre</name><name sortKey="Giacomotto, Jean" sort="Giacomotto, Jean" uniqKey="Giacomotto J" first="Jean" last="Giacomotto">Jean Giacomotto</name><name sortKey="Jin, Ai Hua" sort="Jin, Ai Hua" uniqKey="Jin A" first="Ai-Hua" last="Jin">Ai-Hua Jin</name><name sortKey="Lewis, Richard J" sort="Lewis, Richard J" uniqKey="Lewis R" first="Richard J" last="Lewis">Richard J. Lewis</name><name sortKey="Mohialdeen, Hoshyar" sort="Mohialdeen, Hoshyar" uniqKey="Mohialdeen H" first="Hoshyar" last="Mohialdeen">Hoshyar Mohialdeen</name><name sortKey="Vetter, Irina" sort="Vetter, Irina" uniqKey="Vetter I" first="Irina" last="Vetter">Irina Vetter</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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